Discovered by Elmo de Witt, for whom she made her debut film Vergeet My Nie (1976).
Krige originated the role of the Borg Queen in the film Star Trek: First Contact (1996), but chose not to reprise her portrayal on Star Trek: Voyager (1995). Actress Susanna Thompson played the Borg Queen four times on "Voyager", but she was unavailable during the filming of the series' final episode (she could not fit it into her shooting schedule for Once and Again (1999)), so Krige resumed the role for the finale.
Is one of two very famous "Star Trek" movie villains to reprise her/his role. She played the Borg Queen in both Star Trek: First Contact (1996) and the Star Trek: Voyager (1995) episode "Endgame".
Attended Rhodes University, where she received her honors degree in drama. She later received an honorary Litt.D degree from the university in April 2004.
She was awarded the Saturn Award for her work as the Borg Queen in Star Trek: First Contact (1996).