Born in McKees Rocks, Pennsylvania, attended Sto-Rox High School, and was raised in Pittsburgh, Pennsylvania. Later dropped out of West Virginia University and worked for his father's hazardous waste company before moving to Atlantic City in 1983.
Father, with Dolores May, of Billy Mays III (born in 1985), and, with Deborah Mays, of Elizabeth Mays (born in 2006).
After meeting Orange Glo International founder Max Appel at a home show in Pittsburgh in the mid-1990s, Mays was recruited to demonstrate the environmentally friendly line of cleaning products on the St. Petersburg-based Home Shopping Network.
Best friend and partner of fellow pitchman, Anthony Sullivan.
Appeared in a commercial for the "Jupiter Jack" hands-free phone system.