Wrote the book "Time on Fire: My Comedy of Terrors" (about his experience of being a leukemia patient) that was published in 1996 by Little, Brown, and Company. This book is reviewed and written about in great deal in the January, 2003 issue of "The Oprah Magazine" in an article about patient health-care advocacy.
Participated in the 3rd Munchkin's Project Pink annual breast cancer awareness campaign to raise money for breast cancer research. The project consists of the donation of celebrity-decorated and autographed bath ducks, put up for auction. [October 2008]
Daughter, Sofia Clementina Handler, born 17 January 2007.
Brother of Lowell Handler
Dropped out of the Broadway production of "Biloxi Blues" when he was diagnosed with cancer. He was Matthew Broderick's understudy. He also played "Harold" in the touring company of "Master Harold and the Boys", a role which Broderick had played in a television production, and he appeared on Sex and the City (1998), with Broderick's wife, Sarah Jessica Parker.