In two bull riding scenes, one at the beginning of the movie and one at the end, the gate handlers and rodeo clowns are wearing exactly the same clothes. This would be unlikely since, in the time line of the movie, these scenes take place years apart. It suggests that the scenes were filmed at the same time with no costume changes between scenes.
The airport terminal that Ron Woodroof walked through after arriving in from Japan does not resemble Dallas/Fort Worth International Airport interior design at all. A large poster, 'Dallas International Airport Welcomes You', omitted 'Fort Worth' in the name.
The film is based on the true-life tale of Ron Woodroof, an AIDS patient who began smuggling unapproved pharmaceutical drugs into Texas when he found them effective at improving his symptoms.