Kevin Kline requested that his wife, Phoebe Cates, take a small role in the film. She appeared in the bar/disco scene as the girl Joey picks up at the bar. She did this as a cameo appearance and as a favor to her husband. She was also filming Drop Dead Fred (1991) at the time of her cameo in this film which is why her hair looks exactly the same in both films.
First time co-starring for River Phoenix and Keanu Reeves who forged a strong friendship the previous year when Reeves was making Parenthood (1989) in which he played alongside Phoenix's off-screen girlfriend Martha Plimpton and his younger brother Joaquin Phoenix. Reeves and Phoenix would begin talks with Gus Van Sant during filming and subsequently star together again in My Own Private Idaho (1991) the following year.
When Joey is walking into the Police Station near the end of the movie to drop the charges against his wife and the others, he is wearing black trousers, but while he is talking to detectives Schooner and Wiley they are light colored.
Joey and Rosalie are in the car, with mama Nadja outside trying to persuade Rosalie to get out of the car because it is about to blow up. As Rosalie understands and tries to shield her head there is a piece of cake/bread in her right hand. However, as the shot returns to her, it is in her mouth.