When Burke & Eloise are on their first date, they are seen exiting the Water St. Cafe, which is a real restaurant in Vancouver, British Columbia, where parts of the movie were filmed. www.waterstreetcafe.ca
Jennifer Aniston was never in Seattle during shooting of the film. Her face is never seen during the scenes depicting Seattle landmarks, a body double (who always faced away from the camera) was used instead.
When Walter enters the hotel lobby and sees Burke, he puts the "A-OK!" lanyard on backwards, with the solid blue side facing out, and the camera cuts to a smiling Burke. When it cuts back to Walter, the lanyard is around his neck with the name tag side correctly facing outward.
When Burke is first seen sitting in his hotel room early in the film, in "Seattle" outside his window the Space Needle is nowhere to be seen. The next time he is in his room looking out the window, it is very prominently there.
When Eloise takes Burke to visit her mom before the concert, snow can be seen on the roof of a neighbor's house. It isn't seen snowing during any of the scenes prior to that, but several days of rain are shown. Any snow would likely have melted or been dissolved away by then.
Burke: I happen to know a thing or two about people. You get approached a lot. Probably have since the day you strapped on your first training bra. But you're smart, and you're creative, and you're caring and big... But, how come the guys only see the package it comes in, sure... you're flattered. But ultimately, ultimately it's tiresome because it has nothing to do with you. You were born that way, you can't take credit for it. Your insides though, that's yours. That's what you want someone to truly see. Even a stranger. Ergo... you fake a handicap. Rather than to have a conversation with a fellow human being. You prefer sign language? Fine.
Eloise: Can I say something? And, and this comes from a place of total humility. With the acknowledgment that my life is a day-by-day experiment in... really bad decisions. But, er... you're really messed up.
Burke: [first lines, in voice-over]
Chapter one. Sometimes, despite your best efforts otherwise, life will give you lemons. When that happens, you've got two choices, friend: you can wear a sour face or make lemonade.