Don Johnson's son, Jesse Wayne Johnson, appears in the movie with his then-stepmom, Melanie Griffith. He is the blonde headed boy, sitting in the class, when she comes through the window (for the anatomy lesson). You see him laughing and he even makes a comment.
Jonathan Jackson screen-tested for the role of Frank Wheeler. The final choice for the part was between Jackson and Michael Patrick Carter, who won the role.
Vee flushes and identifies a "Glossy Ibis." This species ranges only within about 50 miles of the south Atlantic and Gulf coasts, and would not occur as far inland as Pittsburgh, the locale of the story.
When Vi is walking to Main Street), Frank brings her a vanilla ice cream cone which then jumps repeatedly from her right hand to her left between shots.