Originally Larry Lamb was due to join the regular cast in Series 4 (1996), playing Dr Richard Carey, with Jane Wymark playing his wife. However their characters were dropped after four episodes had been filmed; some scenes in those episodes had to be edited or re-shot. New producer Richard Handford left abruptly and Michele Buck (producer of earlier series) was asked to return.
In Series 5, Will and Kate's baby, Emily, is treated at a cystic fibrosis unit in Bristol which is named after Vanessa Machin, a cystic fibrosis sufferer (played by Susannah Corbett) who appears in episode Peak Practice: Other Lives (1995).
Alice North had her gall-bladder removed twice during the series: firstly in Series 1 Peak Practice: Listening Skills and then again in Series 5 Peak Practice: Letting Go.