Vince Vieluf who portrays Blaine Cody, did not appear on any of the film's posters or promotional material, even though he is one of the main characters, due to an agent who tried to secure star-billing. Vieluf has since fired the agent.
"Rat Race" has an extremely similar plot to the film It's a Mad, Mad, Mad, Mad World (1963), in which a group of strangers are caught up in a mad dash to seek out and claim $350,000 in cash. That amount adjusted in inflation from 1963 to 2001 would come out approximately to $2,000,000 - the same amount of money Donald Sinclair offered to the 6 random gamblers. Whether or not this was intentionally written into the script as an homage to the 1963 film is unknown.
This film features three Oscar winners: Cuba Gooding Jr. (Best Supporting Actor for Jerry Maguire (1996)); Whoopi Goldberg (Best Supporting Actress for Ghost (1990)), and Kathy Bates (Best Actress for Misery (1990)).
The bullet that was fired and travels next to the rocket car defies the laws of physics. Assuming that the bullet was fired parallel to the ground, the bullet should remain in the air for the same length of time as it would take to drop the bullet from the same height. The bullet in this scene remained in the air for a much longer period of time.
When the truck gets stuck at the top of the tower, the rope coming off of the radar is shown slack. With the tension caused by the weight of the truck and rotation of the radar, the rope should be taut.
When the Squirrel Lady gives Vera and Merrill directions, she says, "Go 5.4 miles and you'll see a yellow sign with some graffiti on it...". When they see the sign, Merrill says, "We're at 2.4 miles exactly!" which is incorrect.