Contrary to popular belief, Samuel L. Jackson's agent insisted that the title be changed, because Jackson "couldn't" work on a film with such a title. When Jackson heard about all of this he responded with the much cited comment, "We're totally changing that back. That's the only reason I took the job: I read the title."
When the hole in the side of the plane, shot out by agent Flynn is first shown, it is on the left hand side of the plane from the pilot's point of view. This is further shown when the snakes fly out the window, as they fly out and to the left as it as shot. When the shot moves to the outside of the plane, the hole is now on the opposite side of the aircraft.
Troy leaves the plane first on the escape slide. In the next shot he can be seen inside the plane again coming down the stairs behind the crowd waiting for their turn on the slide. The DVD audio commentary claims that this error was known but not deliberate.
While escorting surfer dude Sean Jones (Nathan Phillips), witness of a murder committed by notorious gangster Eddie Kim (Byron Lawson), on the South Pacific Airlines red-eye flight from Honolulu to Los Angeles, FBI agent Neville Flynn (Samuel L. Jackson) is forced to fight off a cargo load of venomous snakes unleashed on the Boeing 747 by Kim and his thugs in order to bring down the plane and prevent Jones from testifying.
A Note Regarding Spoilers
The following FAQ entries may contain spoilers. Only the biggest ones (if any) will be covered with spoiler tags. Spoiler tags have been used sparingly in order to make the page more readable.
How do the snakes get from the cargo hold into the passenger compartment?
The co-pilot accidentally releases the oxygen masks in the passenger compartment, and the snakes drop into the cabin with them. Later, Agent Flynn discovers, while crawling into the cargo hold, that a door that separated the compartment from the rest of the plane had been left open.