The film was originally titled "Slammer" until Madonna wrote and decided to use Who's That Girl as the film's theme song. The song went to #1 on the Billboard chart in August 1987.
Originally, Sean Penn was set to co-star with Madonna but after their movie Shanghai Surprise (1986) flopped, the producers opted to go with Griffin Dunne instead, fresh from his success with After Hours (1985).
In the parking garage, Louden is driving erratically because he is not wearing his glasses, after he parks off the side of the building, Louden is swinging on the door, hovering over the water, without his glasses on, the next scene he appears with his glasses on.
When Loudon flips through the pre-nuptial agreement, the first few text pages he flips through are identical. When he gets to the sexual position diagrams, the various icons repeat on various pages. This is because Wendy's father wants to make sure Louden and Wendy don't have sex. It is his way of overkill.
When Louden arrives in Harlem after the hospital, he puts on his pants backwards, you can see the button and zipper when he is laying on the hood talking on the phone, the next scene his pants are on the right way and zippered
Nikki Finn: [pointing at wall with "dead end sign" into which she has just crashed a car]
I'm sorry officer but my husband, see, he's having a heart attack and I had to rush him to the hospital and I must not have been paying attention because I took a wrong turn and is this the way?