Constant references apples and props were a joke on the fact Tasmania is Australia's largest producer/supplier of apples, so much so that the official state slogan printed on Tasmanian car license plates is "Tasmania: The Apple Isle".
Marie's farewell letter is based on a quote by Isaac Newton: "I do not know what I may appear to the world, but to myself I seem to have been only like a boy playing on the sea-shore, and diverting myself in now and then finding a smoother pebble or a prettier shell than ordinary, whilst the great ocean of truth lay all undiscovered before me."
When Albert and Marie arrive at the Science Academy Awards - Einstein say that he's taking the hot air balloon down - and then proceeds to pull the cord to turn on the burners - which should take the balloon up - instead it goes down.
When Marie talks to Albert in the Lunatic Asylum's shower room, "If you won't do anything, who will?" is dubbed over "If you won't do anything, I will."
Albert Einstein: That's it! That's the theory of relativity! Light travels to us from the hands of the clock, to tell us the time. But, if we were to travel away from the clock at the speed of light...