Children with Lorenza Newton: Mariana Del Toro' and Marisa Del Toro.
Was asked to direct End of Days (1999), but he turned it down.
States Mimic (1997) as the worst of his films and has disowned it, blaming constant interference from the producers as the reason for the poor result.
He is friends with fellow successful Mexican directors Alfonso Cuarón and Alejandro González Iñárritu.
In a January 2007 interview on the radio program "Fresh Air with Terry Gross," said that his strictly Catholic grandmother was a "Piper Laurie in Carrie (1976)" figure in his childhood. He told Gross that his grandmother would require him to mortify himself in self-punishment, in one case placing metal bottle caps into his shoes so that the soles of his feet were bloodied while walking to school. She also tried to exorcise him twice because of his persistent interest in fantasy and drawing monsters from his imagination.