In a January 2007 interview on the radio program "Fresh Air with Terry Gross," said that his strictly Catholic grandmother was a "Piper Laurie in Carrie (1976)" figure in his childhood. He told Gross that his grandmother would require him to mortify himself in self-punishment, in one case placing metal bottle caps into his shoes so that the soles of his feet were bloodied while walking to school. She also tried to exorcise him twice because of his persistent interest in fantasy and drawing monsters from his imagination.
His favorite movie monsters are Frankenstein's Monster and the Creature of the Black Lagoon.
Turned down a chance to direct I Am Legend (2007), One Missed Call (2008), Harry Potter and the Half-Blood Prince (2009) and Halo to work on Hellboy II: The Golden Army (2008).
Children with Lorenza Newton: Mariana Del Toro' and Marisa Del Toro.
In an article in USA Today (August 22, 2011), del Toro listed his 6 favorite fright flicks: "Freaks" (1932), "The Uninvited" (1944), "The Innocents" (1961), "Jaws" (1975), "Alien" (1979), and "The Shining" (1980).