She made guest appearances on all three of the longest running North American science fiction series: The X-Files (1993), Stargate SG-1 (1997) and Smallville (2001).
Was originally asked to audition to play "Lori" in Freddy vs. Jason (2003), but when she arrived, director Ronny Yu asked her to audition for the role of "Gibb", claiming she would better suit a more liberal role. Katharine reluctantly accepted.
She said that when she went to a pharmacy after a day of shooting Ginger Snaps (2000), the people there thought she'd been beaten up since she was still covered in fake blood.
Both Katharine Isabelle and Emily Perkins (her co-star in the Ginger Snaps (2000) movies) have guest starred on Supernatural (2005) and Da Vinci's Inquest (1998); but in different episodes.
Katharine refuses to do nude scenes, and has had a body double for every instance where such a scene exists, including the bed and shower scenes in Freddy vs. Jason (2003), the rising from the bed scene in Ginger Snaps Back: The Beginning (2004), and the bed scene in Engaged to Kill (2006), to name but three. The same woman body-doubled the latter two.