Sister-in-law of Charlie O'Connell.
Along with Ian McKellen playing Magneto in the first three live-action X-Men films, James Franco & Willem Dafoe as Harry Osborn and Norman Osborn, respectively, in Sam Raimi's Spider-Man trilogy, Gene Hackman playing Lex Luthor in three (nonconsecutive) Superman films, Cillian Murphy playing Dr Jonathan Crane/The Scarecrow in Christopher Nolan's "Batman: The Dark Knight" trilogy, and Tom Hiddleston as Loki in the expansive Marvel Cinematic Universe series of films, she is one of the few people to play a comic book criminal in at least three live-action films.
Was five months pregnant with her twins Dolly and Charlie when she completed filming on Ugly Betty (2006).
Attended the University of California in Santa Cruz but dropped out in 1991 to pursue her modeling career.
Has appeared in four movies based on Marvel comic book characters: X-Men (2000), X-Men 2 (2003), The Punisher (2004) and X-Men: The Last Stand (2006).