In her guesting at the talk-show Penthouse Live on February 16, 1986 after her first single flopped, host Martin Nievera' suggested Ms. Velasquez to use the more glamorous name Regine, instead of her then name, Chona. Show producer Ronnie Henares also offered to manage her career which she accepted.
Introduced in The Untouchable Family (1988).
Sister, Cacai, is also a professional singer.
At 14, she joined Bagong Kampeon, a television contest featuring the singing talents of Filipinos. She qualified with "Saan Ako Nagkamali", chosen by her father, and won with "In Your Eyes". The prize was a record deal from Octo-Arts.
She mostly directed her own concerts, music videos and TV shows.