The "Jogger", played as himself by legendary "B" producer Lloyd Kaufman (of Troma Films fame), was originally to be called "Handsome Jogger", but was renamed when Kaufman, who was visiting Los Angeles, agreed to a cameo in the film.
As one of many inside jokes, producers Shaked Berenson and 'Patrick Ewald' (qav) doubled for lead actors Greg Grunberg and Lombardo Boyar. Three of these shots ended up in the final cut.
Greg Grunberg's character refers to the spider several times as "poisonous". The correct term is "venomous". Being an exterminator, he would know the difference.
When Alex and Jose are leaving the Hospital and Jose is opening the opaque glass door, the lighting equipment is visible. You can see a tripod behind the door.
This film is about a female mother spider (I believe it is a black widow species spider) that grows and grows. It is exciting and very entertaining for a non-serious comedy, if that is your taste.