AYes. It involves a much more damaged Laurie, and more clarification on why "Deborah" wants Michael to kill Laurie. Laurie and Annie don't get along quite so much, and are at each other's throats for much of the movie, and the ending is almost completely different: After Loomis goes into the shack, and "Deborah" tells Michael to "take us home," Loomis and Michael emerge from the shack. Michael removes his mask, and yells "Die!" at Loomis, before stabbing him. Brackett and the police open fire on Michael and he dies. After this, Laurie walks out of the shed, in shock. She takes the knife from Michael's corpse, and proceeds toward Loomis. Before we can see her intentions, a trigger-happy cop shoots her. Brackett screams for them to hold their fire, but they continue, and Laurie falls dead. Note, the epilogue scene from the theatrical follows, rescored and recut, but it is alluded to that this is merely a symbol for Laurie's descent into madness. However, this could be interpreted as though she survived. According to Zombie, she is dying as that scene plays, and is dead once the first credit hits the screen. A very detailed comparison between both versions with pictures can be found here.
ADeborah Myers (Sheri Moon Zombie) appears in Michael's and Laurie's mind. She tells Michael that he needs to kill his sister in order to bring their family back together. Young Michael Myers (Chase Wright Vanek) appears with Deborah, along with a white horse.
AThis film is a sequel to Halloween (2007), not a remake of Halloween II (1981). The beginning of the film is similar to the original Halloween II, but then the film jumps ahead one year and becomes its own film. Director Rob Zombie was quoted in an interview with the St Petersburg Times as saying: "It's really a character piece on Laurie (Scout Taylor-Compton) and Dr Loomis (Malcolm McDowell), these really damaged people trying to carry on with their lives."