The melody in the song "Hay Amores" (Bolero) sung by Shakira in this film is based on an anonymous traditional popular song called "La Panaderita" (The little baker woman) from the small town of Torrecilla en Cameros, La Rioja, Spain. Whether intentionally or by pure coincidence is not clear. The lyrics in Shakira's song are totally different, of course.
Producer Scott Steindorff spent over 3 years courting Gabriel García Márquez for the rights to the book telling him that he was Florentino and wouldn't give up until he got the rights.
When Dr. Juvenal Urbino visits Florentino Ariza he asks him
what kind of music Ariza likes. "The music of Carlos Gardel", Ariza answers. The time of the action is somewhere between 1890 and 1895. Gardel was born between (the date is not confirmed) 1883 and 1897. So, he was just a kid at that time, and he couldn't be known at all as the famous singer that died in a plane crash in Medellin (Colombia) in 1935, at the age of 48 or 52.
The wedding of Dr. Juvenal Urbino and Fermina is a Modern Catholic Mass. Actually, during the late 19th century and the first decades of the 20th century a Traditional Latin Mass would had been conducted instead.
The trip that Florentino Ariza takes upriver where he experiences his first 'tryst', prominently features a zipper being (un)zipped. Since the zipper was not invented until 1913, nor patented until 1916, this would have been some feat.
Florentino Ariza: Please allow me to wipe the slate clean. Age has no reality except in the physical world. The essence of a human being is resistant to the passage of time. Our inner lives are eternal, which is to say that our spirits remain as youthful and vigorous as when we were in full bloom. Think of love as a state of grace, not the means to anything, but the alpha and omega. An end in itself.