Sandra Bullock was originally cast as Rafi. Bullock wanted major script changes from writer/director Ben Younger but when he refused, she dropped out. Only two weeks before principal photography, Uma Thurman stepped in and replaced Bullock.
Like his character David Bloomberg, Bryan Greenberg was born to psychologists Denny and Carl Greenberg, he has a younger sister, Becca and, he was raised in Conservative Judaism.
In an early scene outside and inside a cinema, which has two screens, the sign above the entrance shows that Screen 1 is showing one movie and Screen 2 is showing another movie. But in an interior scene, a sign shows that the movies are reversed.
When Lisa is talking to her therapist the first time about whether or not to continue treating Rafi, at first her hair is behind her glasses. The next shot her hair is outside of her glasses, and the third shot her hair is behind her glasses again.
When David and Morris are going to throw the pie, the shot of the Verazzano Bridge is a different location than the background scenery when they are talking to each other. The bridge shot is from 3rd avenue on 100th street, while the background shots (when they're talking to each other and are shot from the front) are from elsewhere.