AEddie Brock Jr. could be brought back for a sequel or spin-off. Additionally, the Symbiote is still alive in a couple places -- remember that Dr. Connors still has a piece of the Symbiote. It is widely believed that the Symbiote that Connors has will eventually bond with the yet-to-be-introduced character of Cletus Kasady to form Carnage, as was the case in the comics that Carnage was created in Venom's wake. It was recently announced in July, 2008 that there is now Venom spin-off in early pre-production that will follow Spider-Man 3. However, Topher Grace may not return for the role, as there have been several other hosts to the Venom Symbiote in the comics that could be used in a solo film, including the short lived Angelo Fortunato, and the Scorpion aka "Mac" Gargan. Eddie Brock, meanwhile, had the bits of Symbiote left over in his blood bond to his white blood cells, giving him a new white Venom-like suit. Along with a more altruistic attitude, Brock calls himself Anti-Venom. A potential spin-off could follow either of these plots. Source