AActually, it was Dr. Kimble that was the intended target, not Helen. Sykes had been hired by Dr Charles Nichols to kill Richard. Pay close attention: at the fundraiser, Nichols gives Richard back the keys to his car after having borrowed it. The events of the rest of the night are assumed when Gerard is looking over the phone records: Nichols phones Sykes from Kimble's car and then stops at the house to unlock the door. The plan was to kill Richard after he and Helen came home from the benefit. Unfortunately, Richard is called away to assist at a surgery. When Sykes gets there, Helen is the only one at home. Why Sykes kills Helen instead is unknown. Did she walk in and surprise Sykes? Did Sykes decide to frame Richard for murder? Or did he plan on killing both Helen and Richard to eliminate any potential witnesses? The answer is never revealed. Later in the movie, when Kimble asks that same question, "Why Helen?", he gets no answer either.
QWhat happens to Kimble after the end of the film?
AThe film doesn't say what happens to Kimble after the film, but it would be safe to assume that he received a new trial. Based on the amount of evidence collected by both him and Gerard, a testimony from Gerard, and the capture of the true culprits, he could easily be found innocent. Whether or not he could resume his former life practicing vascular surgery is unknown.
QWell then, why did they want to kill Dr Kimble?
ABecause he was beginning to suspect that Provasic, the new wonder drug being developed by the Devlin MacGregor Pharmaceutical Company, was not so wonderful at all. Kimble was seeing more and more of the patients in the Provasic research program coming to surgery with severely damaged livers. The very night of Helen's murder, in fact, Kimble was called to perform surgery on yet another Provasic patient. The claim that the drug worked with no side effects, which Kimble was going to challenge, would have halted the release of the drug for general use and cost the drug company millions.
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