The film's "What's New Pussycat" title song sung by Tom Jones was a hit, received an Academy Award nomination for Best Song, and stayed on the charts for at least ten weeks peaking at No. #2.
Debut theatrical feature film as an actor of Woody Allen. The picture was also Allen's first ever produced screenplay as a screenwriter with the DVD sleeve notes stating "Woody Allen's debut script".
Near the end during the go-cart scene, Dr. Fassbender enters a farmyard in his go-cart and ends up on a horse; however immediately afterwards he is seen driving the go-cart again.
The second time Paula Prentiss attempts suicide the boom mic is visible at the upper left of screen as she is walking out of Peter O'Toole's bathroom. The mic quickly disappears up the screen.