Dr Robert Knox is played in this film by Tom Wilkinson. In real life, his association with the Burke and Hare murders damaged his reputation and ruined his career.
Actors Jenny Agutter, David Schofield and John Woodvine rejoin director John Landis after almost 30 years since they first collaborated on An American Werewolf in London (1981).
In the "multiple dissection" scene Tom Wilkinson uncovers each of the four dead bodies one at a time. But, following a quick edit to the applauding students, in a closer shot one of the bodies is covered up again.
When Burke and Hare stop for a drink and Burke says that they have no money, Hare plucks a half-crown from underneath Burke's cap. The half-crown that is used in the film is from 1902 - 1910 which is nearly 100 years after the film is set.
Lord Harrington: Whomsoever he determines has made the greatest advances in the field of medicine will be awarded the Royal Seal, and a handsome monetary reward.
Hangman: [after Burke's execution]
I know he seemed like a nice guy and all that, and I suppose you have to respect the fact that he made the ultimate sacrifice for love, but he did kill all those people just for money. And that's just evil.