Has a younger sister named Briana Cuoco.
She did six Barbie ads when she was younger.
The episode of The Big Bang Theory (2007) season 7 episode 14 entitled "The Convention Conundrum" is the first episode in which Kaley Cuoco's name is credited in the opening credits as Kaley Cuoco-Sweeting, following her recent marriage to Ryan Sweeting. Ironically, her "revised" name appears while her ex-boyfriend and current "on screen boyfriend", Johnny Galecki's character Leonard was seen using his laptop attempting to purchase tickets to Comic-Con.
Is six years younger than 8 Simple Rules (2002) co-star Amy Davidson, but she played the older sister in the series.
Best friends with Amy Davidson.